Dosage and Efficacy

Trust in 4 dosage strengths to suit your patient’s needs

TOPROL-XL and its authorized generic, metoprolol succinate (distributed by Lannett Company, Inc.), are available in 4 dosage strengths—25 mg, 50 mg, 100 mg, and 200 mg.*

Available in identical dosing options for the authorized generic of TOPROL-XL—
25 mg, 50 mg, 100 mg, and 200 mg*


*Manufactured for Lannett Company, Inc. by AstraZeneca AB, Södertälje, Sweden.

Have confidence in proven efficacy across all 4 doses4

Reduction in SiDBP* and SiSBP with once-daily TOPROL-XL4

Reduction in SiDBP* and SiSBP† with once-daily TOPROL-XL

Results from a US multicenter, randomized, double-blind, placebo-controlled, parallel-group, unbalanced factorial study. In part, it evaluated the antihypertensive efficacy and the safety of once-daily dosing with extended-release metoprolol succinate monotherapy and placebo in adult patients with newly diagnosed or treated essential hypertension.4

Mean baseline SiDBP 100 mm Hg and mean baseline SiSBP 151 mm Hg


*SiDBP=sitting diastolic blood pressure.

SiSBP=sitting systolic blood pressure.

For each dose vs placebo.

  • In hypertension, initiate with 25 mg to 100 mg once daily. Increase at a weekly or longer interval to optimize clinical response. Dosages above 400 mg per day have not been studied1

Safety and Side Effects

3035818 Last Updated 11/14

  1. Papademetriou V, Hainer JW, Sugg J, Munzer D, for the ATTACH Study Group. Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazaide combination. Am J Hypertens. 2006;10(12):1217-1225.